Last modified: 2019-04-24
Abstract
Abstract:
Subject:High blood pressure is the elevation in blood pressure of the arteries. Although the body can tolerate increased blood pressure for months and even years, eventually the heart may enlarge, which is a major factor in heart failure. Tenormin is chemically described as a benzene acetamide, 4- [2-hydroxy 1-3 [methyl ethyl] amino] prosody]. Tenormin has a molecular weight of 266.34 g/mol. Capoten chemically described as a 1-(3-mercapto-2-D-methyl-1-oxoproppyl) -1-proline (S,S), is used for inhibition of angiotensinogen-converting enzyme.
Objective:To compare between the effect of Capoten and Tenormin on lipid profile and liver function in patients with hypertension and to study which of them is sutable for patient whom turned to have diabetes or liver dysfunctions
Patients and Methods:This study done from April 2013 to September 2013. This study includes forty patients with high blood pressure (hypertension) whom divided into two groups: group (A) which included twenty patients use Tenormin as treatment for hypertension and group (B) which included twenty patients use Capoten as treatment for hypertension. All patients admitted to AL-Yarmok Hospital. Control group (C) were included twenty healthy subject matched in age and sex. Lipid profile, GPT, GOT, albumin and glucose were determined by enzymatic method.
Results:The results of group (A) show significant elevation of total cholesterol, LDL, glucose, negative correlation was found between total cholestrol, LDL, LDL/HDL ratio and glucose, the result groug (B) show significant elevation of glucose, negative correlation was found between capoten with total cholestrol, LDL and LDL/HDL ratio.
Conclution:Capoten is more suitable to treat patient with liver dysfunction, while tenormin is more appropriate to treat patient with diabetes mellitus