Abstract

Hyperthyroidism caused by an increase in amount of thyroid hormones (T₃ and T₄) that produced by an enlarged thyroid gland. Methimazole drug is a thioureylene antithyroid drug, which inhibits the synthesis of thyroid hormones. Its chemical formula is C₄H₆N₂S. Methimazole is used to control the symptoms of hyperthyroidism associated with Graves' disease and to maintain patients in a euthyroid state for several years.

Objective: investigate the effect of methimazole drug on lipid profile level and renal function in patients with hyperthyroidism.

Patients and methods: This study conducted during the period from April 2012 to August 2012. This study includes twenty eight patients with hyperthyroidism that divided into two groups: group (A) which included fourteen patients with drug and group (B) which included fourteen patients without drug. All patients admitted to the AL- Baghdad Hospital. Subject matched in age, sex and BMI. In this study: Lipid profile, urea, creatinine, albumin, glucose were determined by enzymatic method.

Results: The results of group (A) show that were significant elevation of glucose and Albumin. Negative correlation was found between glucose, LDL and total cholesterol, the results of group (B) show a correlate between cholesterol and LDL with thyroid hormone.    

Conclusion: The results show a negative correlation between glucose and methimazole that lead to consider methimazole suitable treatment for patient with hyperthyroidisms that have family history with diabetes mellitus.