The new coronavirus, which is now many respiratory illnesses in Wuhan, China, under the name SARS-CoV-2, from December 2019. The illness COVID-19 was brought on by this virus. A worldwide pandemic has been caused by the virus spreading from person to person. The investigation tries assess polymorphism effect with some genes like Interleukin-6 and Interleukin- 10 on susceptibility to covid-19 in Babylon province. A total of (113) cases in this study (63) cases have clinical symptoms of covid -19 patient, (50) blood samples were collected from healthy people as a control group in this study during (November 2021 to February 2022) at Al-Morgan Hospital. There were many demographic data included in the present study such as age distribution, sex distribution, and geographic distribution of covid patients. Among (63) samples from suspected covid -19 patients from different age groups (20 to 80 years old). The three genotypes (CC, CG &GG), respectively (5.31, 38.94, 11.50), and the allele frequency of (C, G) were (44.44, 55.56) for patients and genotypes (CC, CG &GG), respectively (15.04, 23.01, 6.19) and the allele frequency of (C, G) was (60.00, 40.00) for controls. three genotypes (GG, GA &AA), (3.54, 51.33, 0.88) respectively, and allele frequency of (G, A) was (52.38, 47.62) respectively for the patients and genotypes (GG, GA &AA), (7.96, 20.35, 15.93) respectively, and allele frequency (G, A) was (41.00, 59.00) respectively for control people.

Keywords;IL-6, IL-10, genes, single nucleotide polymorphisms, COVID-19 Babylonian, PCR.