Cihan University-Erbil Conferences, 4th International Conference on Biological & Health Sciences (CIC-BIOHS’2022)

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Cytokine Profile as a Prognostic Parameter
Mustafa Thanoon Younis

Last modified: 2022-08-30


Burn injuries of the skin are one of the most common household injuries which vary depending on the way of induction and its severity. Common complications are sepsis of the wound and immunosuppression. A total of 44 burned patients were included in the study. Blood samples and a swab were taken from the location of burn from each patient. All cytokines (IL-5, IL-6, IL-10, G-CSF, TNF and IFN) were evaluated using the ELISA technique. Swabs were cultured and the bacterial growths were tested for sensitivity to 20 different antibiotic discs. Hematological tests were performed and compared to the healthy group control using the automated five parameter counter. The mean serum levels of the cytokines in both female and male patients were significantly higher when compared to the healthy control group. Hematological parameter level results showed an increase in WBC count in both female and male samples, eosinophil and lymphocyte levels decreased in both genders. Neutrophils have significantly increased in both female and male samples. Monocytes, basophils, and RBC count showed no significant difference in both female and male patient samples. The mean concentrations of Hb and platelets have significantly increased in males but no significant difference in female samples. In the bacteriological cultures, only 21 samples showed a bacterial growth. 14 were females and 7 were males. 7 Gram negative bacteria and 13 Gram positive bacteria were detected. 6 total bacterial species were identified (Enterococcus, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Enterobacter, and Pseudomonas). Antibiotic sensitivity results showed that the number of sensitive bacteria was significantly higher than the resistant bacteria. 14 of the patients had 3rd degree burns. 5 had 2nd degree burns, and 1 had 1st degree burn.Further immunological studies are required to interpret the high mortality rates in burned patients.

Keywords: Cytokine, Prognostic, Burn



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