Typhonium flagelliforme (T. flagelliforme) was utilized in outdated medication for handling numerous syndromes. This study aimed to investigate hepatoprotection effects of T. flagelliforme against thioacetamide (TAA) hepatotoxicity in rodents.Thirty rodents arbitrarily separated five clusters. Collection 1 was intraperitoneally injected distilled water thrice /week and fed (p.o) daily with 10% Tween 20 to eight weeks. Collection 2-5 i.p. injected with 200 mg/kg TAA three times thrice per week for 8 weeks and fed 10% Tween 20, 50 mg/kg silymarin, 250 and 500 mg/kg of T. flagelliforme extract daily for 8 weeks, respectively.Hepatotoxic assembly showed suggestively rise hepatic biochemistry markers together with a considerable lessening of proteins and albumin compared to normal assemblage. The hepatotoxic group displayed decreased catalase and superoxide dismutase activities and increase lipid peroxidation. Macroscopy of hepatotoxic liver exhibited irregular, rough surface with micro and macro nodules, and histopathology-stained Hematoxylin and Eosin, and Masson’s Trichome exhibited inflammation infiltration of lymphocytes, focal necrosis, fibrosis, and bile duct propagation.T. flagelliforme fed clusters have expressively reduced TAA toxicity in gross and histology as designated by fewer disturbances of hepatic tissue, slight fibrosis, and low-grade cells infiltration. Thus, our results showed that the hepatoprotective effect of this plant might be due to reduce toxicity, inhibition of hepatocytes proliferation, decrease enzyme markers, increase protein and albumin, increased endogenous enzymes, and reduced lipid peroxidation level.

Keywords— T. flagelliforme, liver cirrhosis, TAA, histology, liver function tests.

DOI: http://doi.org/10.24086/biohs2022/paper.643