Cihan University-Erbil Conferences, 4th International Conference on Biological & Health Sciences (CIC-BIOHS’2022)

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Serum Glycated LDL Levels in Non-Diabetic Subjects and Type-2 Diabetic Patients as an Atherogenic Stimulant
Abdul-Rahman Abdulateef AL-Bazzaz, mohammed qahtan al-khaial, Omar Abdul wahid Al-Ani

Last modified: 2022-08-30


Background: In the early phases of atherogenesis, glycation and oxidative alteration of lipoproteins boost their absorption by macrophages. The measurement of modified LDL particle levels in the blood could thus be another effective tool for identifying people i who iare iat i high risk iof icoronary iartery i diseasei(CHD).Objective: Small-denseiLDLi (Sd-iLDL) ihas been linked to atherosclerosis in particular. Most Arabic countries, including Jordan, Saudi Arabia, Iraq, and others, have not previously examineditheidistributioniofiglycatediapolipoproteiniBi (glyc_apoB) iinilipoproteinsiininon-diabeticianditypei2idiabetes.Subjects and methods: Fasting serum samples from 31 type-2 diabetic patients (DM) and 31 non-diabetic (hyperlipidemic) subjects were analyzed for glucose, HbA1C, total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) (by routine auto-analyzer methods) iand GlycatediLDLi (Gly-LDL) ibyiELISA.Resultsi: Non-diabetic hyperlipidemic participants exhibited substantially greater serum Gly-LDL concentrations than diabetic patients (p=0.037), but diabetes patients had significantly higher FBS and HbA1c concentrations. In diabetic individuals, Gly-LDL was closely linked with LDL (p =0.035), but not with other parameters; in non-diabetic hyperlipidemic patients, Gly_iLDL wasisignificantlyicorrelatediwithiTG (pi=i0.035), VLDL (pi=i0.03), and HDL (p=0.048), but not with other parameters.Conclusioni: Serum Gly-LDL levels were significantly higher in hyperlipidemic non-diabetics but lower in diabetic patients, implying that regardless of glycemic state, significantiglycationiof LDL exists in all hyperlipidemic non-diabetics. Gly-LDL is a simple test to do, and its results may shed more light on an individual'sientireiriskiof coronaryiheartidisease.

Keywords— Atherosclerosis, Diabetes mellitus, Glycated LDL, Hyperlipidemia, LDL.



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