Gastric ulcer is a chronic condition that occurs when the mucosa of the stomach is broken. There is a physiological equilibrium between aggressive factors and mucosal defense. This study aimed to determine the prevention level and efficiency of herbal medicinal plants (Hypericum perforatum) and compared with the omeprazole drug.Many groups were prepared from Albino male rats, first control group (inoculate with H. pylori and fed with standard pellet), Second group, rats inoculated by H. pylori and prevented with aqueous extract H. perforatum in two dosages (250mg/kg, 500mg/kg), Third group inoculated by H. pylori and prevented with standard drug omeprazole at the dose (20mg/kg).The result showed that H. perforatum inhibits (50.65%) stomach ulcer formation with a high dose. Omeprazole's' group results showed (24.50%) stomachs ulcer formation. Although the result of the current study improves, a high dosage of aqueous extracts of plants has more effectiveness than the low dosage of aqueous extracts of plants.

Keywords—gastric ulcer, Helicobacter pylori, antibacterial activity, gastrointestinal tract, peptic ulcer.

DOI: http://doi.org/10.24086/biohs2022/paper.742