Diarrhea is a condition that, despite advances in medical treatment, continues to be a global problem. Alternative medicine has been used for millennia and has remained a vital component of society all across the world. Medicinal plants are an essential feature of alternative medicine, in which locally available plants or parts are utilized to treat diarrhea. Three medicinal plants utilized locally in diarrhea therapy (Boswellia dalzielli Hutch, Carica papaya L., and Parkia biglobosa Jacq) were studied. This research focused on multi-drug resistant Salmonellae and Shigellae bacteria that had been isolated and confirmed. The experimental treatments included varied concentrations of aqueous extracts of the bark and leaves of the three medicinal plants (10, 20, 30, 50, and 100 mg/ml), which were used to screen Salmonella and Shigellae for susceptibility. As a control, distilled water was used. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined in this research. Three replicates are used in the experiment, which is set up in a completely randomised block design. The information gathered was put through an analysis of variance (ANOVA). The means was determine using Duncan Multiple Range Test. The results showed that Boswellia dalzielli, Carica papaya, and Parkia biglobosa inhibited the growth of the microorganisms examined. At 100 mg/ml, aqueous extract of Boswellia dalzielli had the most inhibitory effect on both Salmonella and Shigella isolates. The aqueous extracts of Boswellia dalzielli had the highest effectiveness of (23.00 ± 1.00). Based on these findings, it's possible that aqueous extracts of Boswellia dalzielli (23.00), Carica papaya (13.77), and Parkia biglobosa (17.73) Antidiarrheal medications could be formulatd from this source.

Keywords-Diarrhea, Multidrug Resistance, Medicinal Plants.

DOI: http://doi.org/10.24086/biohs2022/paper.792